Immunological Effects of IL10 Therapy in Psoriasis

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Analysing the immunological effects of IL-10 therapy in psoriasis should lead to an better understanding of its antipsoriatic mode of action. It seems that IL-10 exerts its antipsoriatic activity by effects on different cell populations including T-cells and APCs as well as their mutual interaction. IL-10 is able to suppress the APC activity of monocytes/macrophages and the development of dendritic cells. In fact, depressed monocytic HLA-DR and CD86 expression as well as TNF-a and IL-12 secretion capacities were observed by us during IL-10 therapy. Moreover, IL-10 led to a lasting type 1/ type 2 shift (increasing proportion of IL-4, IL-5, and IL-10 producing T-cells, selective increase in IgE serum levels).1 A significant negative correlation was demonstrated between the IL-4 secretion capacity and Psoriasis Area and Severity Index score was found in our long term trial. The physiological significance of these findings was reflected by the depressed DTH reaction to recall antigens during IL-10 therapy.11,18 Interestingly, IL-10 therapy led to a decrease in cutaneous IL-8 and an increase in IL-4 expression, both of which might contribute to the antipsoriatic effect.13,19 This is supported by the recently reported antipsoriatic effects of IL-4 itself.20 Direct effects of IL-10 on keratinocytes, however, are unlikely to have contributed to the clinical response, since the IL-10 unresponsiveness of keratinocytes has been demonstrated by us recently.21,22

Immunological Therapy

Figure 3. Clinical effects of long term IL-10 therapy in psoriasis.16 A) Individual courses of psoriatic disease under long term IL-10 application to prevent the reoccurenace of disease. The patients dropped out of the analysis when fulfilling the criteria for psoriasis relapse. B) Kaplan Meier analysis of relapse-risk.

Figure 3. Clinical effects of long term IL-10 therapy in psoriasis.16 A) Individual courses of psoriatic disease under long term IL-10 application to prevent the reoccurenace of disease. The patients dropped out of the analysis when fulfilling the criteria for psoriasis relapse. B) Kaplan Meier analysis of relapse-risk.

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