Its considerable anti-inflammatory effects and its ability to act as a main suppresser of cellular immunity2 raises the question of the IL-10 expression under pathophysiological conditions, including in psoriasis.
Immunohistochemical investigations suggested a low cutaneous IL-10 protein expression.3 Similar results were found by quantification of IL-10 protein in blister fluids.4 We found that the cutaneous IL-10 mRNA expression in psoriasis was significantly lower than in atopic dermatitis or cutaneous T-cell lymphoma. The level of IL-10 mRNA expression did not differ from healthy skin, even though numerous pro-inflammatory cytokines are overexpressed. These results are in particular remarkable since TNF, a major inducer of IL-10 was highly expressed. All in all this indicates a relative IL-10 deficiency in psoriasis5 which might have a genetic background.
Remarkably, well established antipsoriatic therapies such as UV radiation or vitamin D analogues are leading to an increase of IL-10 expression in vitro and in vivo.5
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.