IL10 Expression in Psoriasis

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Its considerable anti-inflammatory effects and its ability to act as a main suppresser of cellular immunity2 raises the question of the IL-10 expression under pathophysiological conditions, including in psoriasis.

Immunohistochemical investigations suggested a low cutaneous IL-10 protein expression.3 Similar results were found by quantification of IL-10 protein in blister fluids.4 We found that the cutaneous IL-10 mRNA expression in psoriasis was significantly lower than in atopic dermatitis or cutaneous T-cell lymphoma. The level of IL-10 mRNA expression did not differ from healthy skin, even though numerous pro-inflammatory cytokines are overexpressed. These results are in particular remarkable since TNF, a major inducer of IL-10 was highly expressed. All in all this indicates a relative IL-10 deficiency in psoriasis5 which might have a genetic background.

Remarkably, well established antipsoriatic therapies such as UV radiation or vitamin D analogues are leading to an increase of IL-10 expression in vitro and in vivo.5

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Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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