IL10 and IL10 Receptor Polymorphisms in Psoriasis

Genetic markers in cytokine genes are becoming widely used in studies of immune-mediated disease and it is becoming apparent that they can be markers of disease susceptibility as well as of disease severity.6 When the two known polymorphic microsatellite markers in the human IL-10 promoter IL10.G and IL10.R. were investigated in psoriasis patients, no difference was noted in comparison to the control group. Also, no difference in allele distribution was observed when the psoriasis patients were stratified according to age of onset. However, a clear differential distribution was revealed when patients were grouped according to whether they had a positive family history of psoriasis. In this case, allele IL10.G13 was positively associated with familial psoriasis and this was also true when younger patients were considered - patients with age-of-onset of less than forty were three-fold more likely to have a psoriatic family background if they carried this allele. Thus, it appears that the IL-10 locus contributes to the genetic background in familial psoriasis.7 More recent investigations in a larger population, however, do not support this.8 Further investigations are necessary to determine whether the relative IL-10 deficiency in psoriasis has a genetic origin.

Figure 1. Effects of IL-10 on the T-helper (Th)1/Th2 dysbalance in psoriasis.18 An immune deviation towards a type 1 cytokine aptetrn is a typical finding in several indications such as psoriasis, rheumatoid arthrism, inflammatory bowel disease, transplant rejection, multiple sclerosis. IL-10 reverses the Th1 cytokine pattern present. It promotes the development of a type 2 cytokine pattern by inhibiting the IFN-y production ofT lymphocytes particularly via the suppression of IL-12 synthesis in accessory cells. Moreover it inhibits MHC class II and costimulatory molecule expression.

Figure 1. Effects of IL-10 on the T-helper (Th)1/Th2 dysbalance in psoriasis.18 An immune deviation towards a type 1 cytokine aptetrn is a typical finding in several indications such as psoriasis, rheumatoid arthrism, inflammatory bowel disease, transplant rejection, multiple sclerosis. IL-10 reverses the Th1 cytokine pattern present. It promotes the development of a type 2 cytokine pattern by inhibiting the IFN-y production ofT lymphocytes particularly via the suppression of IL-12 synthesis in accessory cells. Moreover it inhibits MHC class II and costimulatory molecule expression.

Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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