Preliminary studies have been performed in which IL-10 has been administered to healthy adult volunteers.179-184 Recombinant IL-10 is generally well tolerated by healthy volunteers at doses of 25 ^g/kg or less. Higher doses (50 and 100 ^g/kg) have been associated with mild-to-moderate flu-like symptoms of fever with chills and myalgias.183 IL-10 administration resulted in increased numbers of neutrophils, and monocytes. In parallel, platelet counts, CD3+, CD4+ and CD8+ T cell numbers were reduced. IL-10 administration also reduced LPS-stimulated ex vivo production of pro-inflammatory cytokines including TNF-a, IL-1 p, IL-6, and IL-8, and PHA- and PMA-stimulated IFN-y production.180-185 Studies comparing IL-10 with corticosteroids, both alone and in combination, have demonstrated that even low doses of IL-10 (8 ^g/kg) suppressed ex vivo pro-inflammatory cytokine production in a more prolonged and efficacious manner than did corticosteroids.1 0 However, IL-10 did not affect the production of endogenous anti-inflammatory molecules such as soluble TNF-receptor p55 or IL-1 receptor antagonist (IL-1ra).181
Was this article helpful?
Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.