Systemic IL10 as a Therapy for Crohns Disease

Both the role of IL-10 in the maintenance of mucosal homeostasis and the therapeutic efficacy of systemic IL-10 injections in animal models of colitis indicated its potential as a novel therapy in Crohn's disease.37-39 In vitro studies showed that exogenous IL-10 down-regulates the enhanced pro-inflammatory cytokine release from lamina propria mono-nuclear cells isolated from patients with Crohn's disease.28 Furthermore, in an initial trial of 46 patients with steroid-resistant Crohn's disease,...

Role in Allergic Diseases

There is increasing evidence that IL-10 secretion may be defective in patients with asthma.1,47 Lower concentrations of IL-10 are found in bronchoalveolar lavage fluid of asthmatic patients than in normal control subjects48 and there is a reduction in the number of macrophages expressing IL-10 in induced sputum.49 There is a reduced secretion of IL-10 from alveolar macrophages obtained by bronchoalveolar lavage from asthmatic patients compared to normal controls, and this is at the level of...

Crohns Disease A Failure of Mucosal Immunoregulation

Implicit in the function of the mucosal immune system is the ability to mount an immune response to pathogens whilst maintaining tolerance to the vast array of luminal antigens derived from food and commensal bacteria. The fact that many animal models of Crohn's disease remain disease-free if reared in germ free conditions suggest that luminal bacteria are involved in either the initiation or prolongation of intestinal inflammation. Further evidence for this hypothesis is provided by clinical...

IL10 Expression in Psoriasis

Its considerable anti-inflammatory effects and its ability to act as a main suppresser of cellular immunity2 raises the question of the IL-10 expression under pathophysiological conditions, including in psoriasis. Immunohistochemical investigations suggested a low cutaneous IL-10 protein expression.3 Similar results were found by quantification of IL-10 protein in blister fluids.4 We found that the cutaneous IL-10 mRNA expression in psoriasis was significantly lower than in atopic dermatitis or...

Clinical Effects of IL10 Therapy in Psoriasis

The powerful immunomodulatory properties of IL-10 and the promising results from IL-10 delivery on the course of several inflammatory diseases in experimental models induced the interest on clinical application of recombinant human (rh) IL-10 (ilodecakin Tenovil Schering-Plough Corp., USA) After promising data from phase 1 trials in was used in several indications including in psoriasis. The first administration of human recombined IL-10 in human was performed in 1995.9 Overall, these studies...

IL10 as an Anticancer Agent in the Clinical Settings

The anticancer activity of IL-10 in animal models and in human observation suggested that IL-10 could be considered alone or in combination with other agents as an anti-cancer agent.2,7,8,24,25,43,53,74 For instance, an analysis of melanoma metastases suggested the IL-10 secretion by tumor cells is a strong predictor of immune responsiveness to the administration of pro-inflammatory cytokines such as interleukin-2.43,53 In addition, human observations demonstrate that systemic administration of...

Interleukin10 and Human Cancer

The biological significance of IL-10 production by tumor cells has yet to be fully determined and maybe very much dependent on the type of tissue organ in which the tumor is developing. A summary of reported observation on IL-10 expression by human cancers is shown in Table 2. IL-10 is often identifiable in freshly excised human tumors including melanoma, ovarian, breast, renal cell, lung, skin, lymphoma, nasopharyngeal and esophageal can-cer.40-52 In the majority of the cases, IL-10 is over...

Alzheimers Disease

Apoe Inflammation

The neurodegenerative inflammatory age-related disease, Alzheimer's disease AD , is the most common cause of dementia in the elderly. It is a progressive neurological disease that results in the irreversible loss of neurons, particularly in the cortex and hippocampus. The pathological hallmarks are neuronal loss, extracellular senile plaques containing the peptide amyloid-beta Ap and neurofibrillary tangles the latter are composed of a hyperphosphorylated form of the microtubular protein tau....

Immunological Effects of IL10 Therapy in Psoriasis

Analysing the immunological effects of IL-10 therapy in psoriasis should lead to an better understanding of its antipsoriatic mode of action. It seems that IL-10 exerts its antipsoriatic activity by effects on different cell populations including T-cells and APCs as well as their mutual interaction. IL-10 is able to suppress the APC activity of monocytes macrophages and the development of dendritic cells. In fact, depressed monocytic HLA-DR and CD86 expression as well as TNF-a and IL-12...