By Listeria monocytogenes

Lauren A. Zenewicz1 and Hao Shen2

1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA

e-mail: [email protected]

2Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA

Abstract: Listeria monocytogenes has long served as a model pathogen for elucidating many functions of the immune response. Both the innate and adaptive immune systems are crucial to the recognition and elimination of this pathogen from the host. However, although L. monocytogenes infection induces robust immune responses, the bacterium has evolved mechanisms to evade and modulate the immune response. Its intracellular niche allows it to evade several aspects of the innate and adaptive immune systems. Expression of different virulence factors during infection leads to modulation of other arms of the immune response. In this chapter, we focus on the specific mechanisms L. monocytogenes has evolved to evade and modulate the host immune response.

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