FIGURE 17.1 Schematic diagram of the protein-precipitation technique for bioanalysis. (Reprinted from Wells [54]. Copyright © 2003, with permission from Elsevier Science.)

aqueous ammonium sulfate or zinc sulfate heptahydrate (10%, w/v)) and inorganic acids (trichloroacetic acid (10%, w/v), perchloric acid (6%, w/v), and metaphosphoric acid (5% w/v)) are also effective protein precipitating agents [2], but are not commonly used in bioanalysis, since these materials are not compatible for direct injection with LC-MS techniques.

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