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2.20 jl

Time, min

FIGURE 12.7 HLPC-MS/MS chromatograms of the carboxylic acid metabolite (retention time 2.20 min) in rat plasma after (A) 5 minutes, (B) 29 minutes, (C) 53 minutes, (D) 77 minutes, (E) 125 minutes, (F) 149 minutes, and (G) 173 minutes of incubation at 37°C. (Reprinted from Wang et al. [33]. Copyright © 2002, with permission from Elsevier.)

FIGURE 12.8 Graph showing the disappearance of the test compound along with the emergence of the metabolite (degradation product). (Reprinted from Wang et al. [33]. Copyright © 2002, with permission from Elsevier.)

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