Analytical Constructs

Two of the difficulties encountered with solid-phase synthesis is quantitation and identification of all the products that result from resin-based solid-phase methods. "Analytical constructs" were developed to facilitate rapid quantitative and qualitative analytical measurements during compound synthesis and library production [10,11]. The analytical construct designed by Diversity Sciences possesses multiple functions. The construct serves as the physical link between the solid support and the site of synthesis, promotes the analytical analysis of a library synthesis at each step of the procedure, and also provides a facile method of bead encoding.

O Resin Bead E Peak Splitter

Linkerl SÜ Linker2

E Ionizing Group Chemistry

Mass-Code Block Generic Analytical Construct

NH(Boc)

NH(Boc)

O Resin Bead B (G0/G3) Peak Splitter

Knorr Linker !§| Photolinker □ Lys Ionizing Group ^"^Chemistry ^^ Amino Acid Mass-Code Block

Commonly Used Analytical Construct

O Resin Bead E Peak Splitter

Linkerl SÜ Linker2

E Ionizing Group Chemistry

Mass-Code Block Generic Analytical Construct

Chemical

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