Survival Promoting Activity of Caveolin1

Several studies using either overexpression or antisense suppression techniques demonstrated that caveolin-1 may act as a positive regulator of cell survival in certain cancer cells. This was first shown in mouse and human prostate cancer cells, where expression of caveolin-1 protects the cells from androgen deprivation-induced apoptosis and c-Myc-induced apoptosis, respectively [7,10]. In the former case, caveolin-1 was secreted from the cells, upon testosterone treatment, acting as an autocrine or paracrine pro-survival factor [9]. Similarly, overexpression of caveolin-1 in LNCaP human prostate cancer cells significantly reduced thapsigargin-induced apoptosis [12]. The pro-survival action of caveolin-1 in prostate cancer cells was recently confirmed in the TRAMP mouse model, where caveolin-1 gene knockout attenuated tumor progression and metastasis in vivo and stimulated apoptosis of tumor-derived cells both in vitro and in vivo [84]. We have recently shown that caveolin-1 expression in MCF-7 cells results in inhibition of anoikis

(detachment-induced apoptosis) [11] and of detachment-induced activation of p53 [13]. Interestingly, cellular resistance to anoikis was also recently shown to be caveolin-1-dependent in pancreatic adenocarcinoma cells [85]. Antisense inhibition of caveolin-1 expression sensitizes nonmalignant intestinal epithelial cells to anoikis [14]. Taken together, these data clearly indicate that caveolin-1 can promote cell survival upon environmental challenge in both normal and cancer cells.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment