Summary

The roles of caveolin and caveolae in a variety of cellular processes have been reassessed. In particular, responsibility for the regulation of cellular shape determination, migration and stress fiber formation has been reviewed. The mode of cellular polarity can be partially explained by the recruitment and polarization of intracellular caveolin, which might be responsible in turn for cellular motility (Fig. 9.3). Likewise, the interaction of caveolin with Rho GTPases might affect the

Fig. 9.3 Role of caveolin-1 via actin remodeling. Caveolin-1 may involve in morphological changes or migration via regulation of Rho GTPases, focal adhesion formation or actin remodeling. For molecular trafficking, caveolin can interact with F-actin or filamin. These interactions may play a crucial role in the translocation of GLUT4 in adipocytes or endocytosis of viruses.

Fig. 9.3 Role of caveolin-1 via actin remodeling. Caveolin-1 may involve in morphological changes or migration via regulation of Rho GTPases, focal adhesion formation or actin remodeling. For molecular trafficking, caveolin can interact with F-actin or filamin. These interactions may play a crucial role in the translocation of GLUT4 in adipocytes or endocytosis of viruses.

relevant activities for microtubule dynamics, actin remodeling and migration, resulting in cellular morphological changes as well as locomotive activity. Moreover, caveolin's interaction with the focal adhesion kinase complex and actin cytoskeletal structures resulted in the modulation of molecular trafficking for many biologically active molecules. These findings of caveolin function led us to explain, in part, the bimodal nature of changes in structure and function in senescent pheno-types. In this context, the role of caveolin as a determinant of structural change in the senescent cell highlighted the novel modality for the modulation of age-related morphological alteration as well as functional deterioration through the simple adjustment of caveolin status.

In conclusion, it is possible that the status of caveolin - via its interaction with actin cytoskeletal structures, focal adhesion kinase complex and Rho GTPases -may affect a variety of cellular processes such as signaling modulation, viral in-fectivity, hormone sensitivity, transformability, invasiveness and neuronal capacity, among a broad spectrum of cellular phenomena.

Abbreviations

EC

endothelial cell

ECM

extracellular matrix

FAK

focal adhesion kinase

GLUT4

glucose transporter 4

HDF

human diploid fibroblast

IGF-1

insulin growth factor-1

mßCD

methyl- b-cyclodextrin

PI

phosphatidylinositol

SV40

Simian virus 40

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