Cholesterol Homeostasis Regulates Caveolin Localization and Organization of other Proteins in Caveolae

The cycle of cholesterol movement between cell-surface caveolae and intracellular pools rich in cholesterol contributes to caveolae cholesterol homeostasis. This cycle is controlled in a complex fashion that can involve scavenger receptors (SR-BI and CD-36), lipoproteins, and even sex hormones [11,14,65,77,78]. Many studies using methyl-beta-cyclodextrin have documented that cholesterol depletion and repletion cause major changes in the organization of caveolae, caveolin-1 localization to caveolae, or redistribution to intracellular sites, and resultant effects on numerous signaling proteins that are found in association with caveolae or bound to caveolae by caveolin-1. A recent report has shown that shear stress induction of eNOS activity is also susceptible to disruption of caveolae cholesterol, either by methylbeta cyclodextrin depletion, or by cyclosporine A inhibition of caveolin-1-cypA interaction [79]. This indicates that disruption of this chaperone complex cycle contributes to the endothelial pathogenesis which leads to hypertension induced by cyclosporine.

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment