Acknowledgments

The authors are grateful to all members of their group for many helpful discussions. This project was supported in part by a grant from the DKFZ/MOST, and is currently supported by a grant from the Philip Morris Foundation and by intramural grants from the Willner Center for Vascular Biology and the Center for Scientific Excellence. M. L. is the incumbent of the Harold L. Korda Professorial Chair in Biology.

Abbreviations

ACTH

adrenocorticotropic hormone

CSD

caveolin scaffolding domain

eNOS

endothelial nitric oxide synthase

ER-a

estrogen receptor-a

FAK

focal adhesion kinase

IGF-I

insulin-like growth factor-1

IL

interleukin

MDR

multidrug resistance/t

PDGF

platelet-derived growth factor

PDK1

phosphoinositide-dependent protein kinase-1

PI3K

phosphoinositide 3-kinase

PTB

phosphotyrosine binding

SCLC

small-cell lung cancer

SFK Src family kinase(s)

SH2 Src homology 2

TNF-a tumor necrosis factor-a

VSMC vascular smooth muscle cells

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