Acknowledgments

G. Vamosi and A. Bodnar contributed equally to this manuscript. These studies were supported by the following grants: OTKA TS40773, T48745, T42618, F46497; T38037; T43061; ETT 602/2003, 603/2003; 524/2004; 532/2004; NATO Life Science and Technology Collaborative Linkage Grant 980200, EU FP6 LSHB-CT-2004-503467; Bolyai Janos Research Fellowships (to G. Vamosi and A. Bodnar) and Bekesi Fellowship (to G. Vereb).

Abbreviations

P2m

P2-microglobulin

AFM

atomic force microscopy

AICD

activation-induced cell death

APC

antigen-presenting cell

CLSM

confocal laser scanning microscopy

cSMAC

central supramolecular activation cluster

CTL

cytotoxic T cell

CTX-B

cholera toxin B

EGFR

epidermal growth factor receptor

ER

endoplasmic reticulum

FCCS

fluorescence cross-correlation spectroscopy

FCS

fluorescence correlation spectroscopy

FHC

free heavy chain

FLIM

fluorescence lifetime imaging microscopy

FRET

fluorescence resonance energy transfer

ICAM

intracellular adhesion molecule

IFN

interferon

IL

interleukin

IS

immunological synapse

JAK

janus kinase

MHC

major histocompatibility complex

NGF

nerve growth factor

NMR

nuclear magnetic resonance

pbFRET

photobleaching FRET

PDGF

platelet-derived growth factor

PHA

phytohemagglutinin

pSMAC

peripheral supramolecular activation cluster

SNOM

scanning near-field optical microscopy

TCR

T-cell receptor

VEGF

vascular endothelial growth factor

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