Predisposing Factors

Blood

Heredity

Personality/ stress Smoking Diabetes Obesity Activity

I Diet

Alcohol Infections

Stage 1: formation of atherosclerotic plaque in artery wall

Turbulent flow f-

Hypertension Toxinsf

Phospholipid-PUFA

Eicosanoids \

Platelet _ Growth adherence/aggregation factors

ENDOTHELIAL Increased INJURY ~" permea- " bility

Smooth muscle cell proliferation

Collagen synthesis

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