A major difference between phosphoglyceride formation in yeasts and bacteria compared to animals is in the production of phosphatidylserine. In the simpler organisms, phosphatidylserine plays a major role as an intermediate in the production of phosphatidylethanolamine (and phosphatidylcho-line) and is made from CDP-diacylglycerol (Figs 7.4 and 7.5). However, in animals it is made via an exchange reaction in which the head group of an existing phospholipid (usually phosphatidyletha-nolamine or phosphatidylcholine) is exchanged for serine. The reactions have been studied in most detail using Chinese hamster ovary cell mutants
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