Oh

Hydroxymethyl-glutaryl-CoA

CH3COCH2COOH + CH2 COSCoA Acetoacetate Acetyl-CoA

HMG is an important intermediate in cholesterol biosynthesis and this pathway provides a link ch3 o I II CH3CHCH2CSCoA

isovaleroyl-CoA

Acyl-CoA

dehydrogenase ch3

CH3C=CHCSCoA isopentenoyl-CoA

C02-biot«n isopentenoyl-CoA carboxylase ch3 o

I II HOOCCH2ch=chcscoa

3-methylglutaconyl-CoA

Hydratase ch3 o

I II HOOCCH2CCH2CSCoA

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