© © Monoacylglycerol pathway
Fig. 3.6 The biosynthesis of triacylglycerols in mammals. The figure illustrates the three main pathways: the glycerol 3-phosphate (G3P) pathway (reactions 1,4,5, 7), the dihydroxyacetone phosphate (DHAP) pathway (reactions 2, 3, 4, 5, 7) and the monoacylglycerol pathway (reactions 6, 7). The enzymes involved are: (1) glycerol 3-phosphate acyltransferase (GPAT); (2) dihydroxyacetone phosphate acyltransferase; (3) acyl-dihydroxyacetone phosphate reductase; (4) lysophosphatidate acyltransferase (LPAT); (5) phosphatidate phosphohydrolase (PAP); (6) monoacylglycerol acyltransferase; (7) diacylglycerol acyltransferase (DAGAT). A minor route from diacylglycerols proceeds via reaction 8: diacylglycerol transacylase. In some tissues, diacylglycerol can be reconverted into phosphatidic acid by diacylglycerol kinase (9).
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