Ganglioside biosynthesis

Gangliosides contain sialic acid residues that are added using a cytidine derivative. This compound, CMP-neuraminic acid (Fig. 7.14) is formed by an enzymic reaction from CTP and is analogous to the

Table 7.5 Substrates used for the formation of sphingolipids

Group to be added

Substrate used

Glucose Galactose

N-Acetylgalactosamine Fucose

Sialic acid (N-acetyl neuraminic acid) Sulphate

UDP-glucose

UDP-galactose

UDP-N-acetylgalactosamine

GDP-fucose

CMP-NeuAc

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