Geneexpression profiles in the life cycle

The analysis of the Roff (2002) model given at the beginning of this chapter has shown that age at maturation is a very important life-history trait.

Figure 5.8 Model for endocrine regulation of longevity in (a) C. elegans, (b) D. melanogaster, and (c) Mus musculus, showing how environmental cues are translated into neuroendocrine signals, acting upon an insulin/IGF signalling pathway and triggering a variety of hormonal responses, including steroid responses. The ultimate effect is that different priorities are given to gonad versus soma; that is, reproduction and growth versus aging. CNS, central nervous system; FSH, follicle-stimulating hormone; GC, germ-line cells; GH, growth factor; 20HE, 20-hydroxy-ecdysone; INR, insulin receptor; IPC, insulin-producing cells; IR/IGF-1R, insulin receptor/IGF-1 receptor; LH, luteinizing hormone; SG, somatic gonad tissue; TSH, thyroid-stimulating hormone; T3, 3,3',5-tri-iodothyronine; T4, thyroxine. Reprinted with permission from Tatar et al. (2003). Copyright 2003 AAAS.

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