Melanoma is one of the most common leptomeningeal cancers in adults; however, it is infrequently observed in children since melanoma comprises less than 1% of childhood cancers.88'99 Leptomeningeal dissemination of melanoma most commonly occurs in children who have advanced systemic disease, especially underlying CNS parenchymal metastases. Children who have large congenital nevi rarely present with primary leptomeningeal melanoma.88'99 Both primary leptomeningeal melanoma and metastatic leptomeningeal melanoma are rapidly progressive entities for which there is no known effective therapy. In contrast, neurocutaneous melanosis (NCM), a rare phacomatosis characterized by the presence of large non-malignant melanocytic nevi in combination with an excess of melanotic cells in the leptomeninges may be asymptomatic for prolonged periods or have neurologic symptoms with or without associated malignant transformation. The prognosis for patients with neurologic symptoms is generally poor, even in the absence of malignant involvement. 88,100-102
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.