Adaptive Immunity to L pneumophila Infection

Cannabinoid And Adaptive Immunity

The adaptive immune response to bacterial infection follows initial exposure to microbes, not necessarily active infection, and is transferable to naive recipients by lymphocytes. The humoral antibody response to bacterial infection is a typical adaptive immune response when an individual is exposed to bacterial antigens and a heightened specific antibody response then occurs after secondary stimulation by antigens from the same microbe or active infection. The role of antibodies in resistance...

The Life Cycle of L pneumophila as Currently Understood

Legionella Pneumophila Life Cycle

Life cycles tell us a great deal about the natural history of a living organism. They are a synthesis of years of evolution, adaptation, specialization, and survival in nature. From an infectious disease standpoint, life cycles may provide clues to understand the mechanisms of pathogenesis of a particular parasite. The origin of pathogens and the evolution of virulence lie within the dominion of microbial ecology, and the life cycle of L. pneumophila surely is no exception. Amoebae are the...

Clinical Features of Legionnaires Disease

A listing of symptoms and signs in patients with LD does not accurately convey the clinical features of the disease. While, as will be subsequently described, there are no features of LD that allow one to make the diagnosis clinically, there is little doubt from clinical observations that in young adults with no comorbidity who develop rapidly progressive pneumonia LD has to be near the top of the differential diagnosis. In the Philadelphia outbreak Tsai et al 1979 fever was present in 97...

Life Cycle of L pneumophila

Life Cycle Legionella Pneumophila

When planktonic, transmissive L. pneumophila are engulfed by phagocytic cells, the bacteria avoid lysosomal degradation and instead establish vacuoles isolated from the endocytic network Fig. 6.1 . To gauge nutrient conditions within its host cell, L. pneumophila employs the Pht family of transporters Sauer et al. 2005 . If vacuolar conditions are favorable, the post-transcriptional regulator CsrA, and perhaps the sRNA chaperone Hfq, suppress transmissive traits and promote intra-cellular...

Preface and Introduction

The summer of 2006 marked the 30th anniversary of the outbreak of Legionnaires' disease, an acute pneumonia that occurred among veterans who had gathered in Philadelphia, Pennsylvania, in 1976 to celebrate the bicentennial of the founding of the United States. Ironically, the nation and world were braced for an epidemic of swine influenza, which never materialized and no one expected the emergence of a new bacterial pathogen, since most in the medical field sincerely believed that all the...