Vaccination

Among the multiple mechanisms that microorganisms have invented to acquire iron, some may lend themselves to preventive medicine by vaccination. Two such microbial strategies, manipulated to the benefit of the host, are briefly discussed here. First, the critical role played by Tbp and Lbp subunits in bacterial iron acquisition from host-specific Tf and Lf suggests that these receptor proteins may serve as good candidates for vaccination. Understandably, most of the work in this direction has...

Sources of Dietary Iron in Man and the Importance of Luminal Factors

The capacity of the human body to excrete iron is severely limited as compared with most other mammals Finch et al., 1978 . Iron loss in human beings per kg body weight is only one-tenth that of other mammals Dubach et al., 1955 Green et al., 1968 Finch et al., 1978 and human dietary intake only one-fiftieth to one-hundredth that of other mammals. It follows, as was originally suggested by McCance and Widdowson 1937 , that iron balance in man is primarily determined by iron absorption. There is...

Iron Transfer Across the Mucosal Cell

Mobilferrin Paraferritin

The transfer step involves the passage of iron that has been taken up at the apical, brush border membrane across the mucosal epithelial cell to the basolateral membrane, where it is transferred to the circulation. However, not all the iron taken up from the lumen into the cell is transferred. As a function of the body's requirements for iron essentially determined by the rate of erythropoiesis a variable proportion could be sequestered within the mucosal cell, eventually to be discarded into...

Iron Absorption in Disorders of Iron Metabolism

Shadow Shield Whole Body Counter

The mechanism of iron absorption, and the involvement of recently detected proteins in iron transport, is described in detail in Chapter 8. Our understanding of iron absorption at the molecular level is growing rapidly. This knowledge is essentially based on detailed quantitative information on iron absorption in normal subjects, in patients with iron deficiency, hereditary and secondary iron overload, and inflammation Heinrich et al., 1966 Marx, 1979a Werner and Kaltwasser, 1987 Wienk etal.,...