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The major short-acting insulin and analogs are Regular, aspart, and lispro. Aspart and lispro have a faster onset and shorter duration of activity that more closely mimic the "normal" insulin response to a meal, which is viewed as their major advantage. However, somewhat paradoxically, their major drawback is also the

short duration, which may result in periods of "underinsulinization" in some patients with type 1 diabetes. This may be obviated by the longer-acting analog insulin glargine (42-44,47). The latter has a longer duration and is more predictable than the other intermediate- and longer-acting insulins: NPH, Lente, and Ultralente. Newer analogs are in development to address problems of stability, variability of absorption, and selectivity. An example is Insulin detemir (Lys BM[N£-tetradecanoyl] des B30) human insulin. In the presence of zinc and phenol it is mainly hexameric, and it also has a fatty-acid side chain. This results in aggregation of hexamers, resulting in a slowly and more predictably absorbed insulin-like molecule (48). It is less potent than NPH, but less mitogenic than insulin glargine (29). Hopefully, newer analogs will provide even better tools for mimicking the physiological insulin profile.

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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