Glucose Uptake by Insulin Independent Tissues

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Some glucose transporter isoforms do not require insulin in order to be translocated to the cell membrane. For example, the glucose-2-transporter protein—the predominant form in the liver and the endocrine pancreas—remains in the cell membrane independent of insulin action. As a result, glucose is taken up passively down its concentration gradient into cells by these constantly available glucose transporter proteins. This allows the liver to take up glucose when the blood glucose concentration is high after a meal, and so replenish liver glycogen stores. Likewise, it allows the pancreatic endocrine cells to "sense" the blood glucose concentration and release insulin (p cells) and glucagon (a calls) accordingly.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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