Q

Hepatic proteins, 90-92

Hepatic triglyceride lipase (HTGL), 89

Hexokinase, 2

High density lipoproteins (HDL), 49, 87, 124, 140 hypoglycemic agents, 97 reverse cholesterol transport, 92-95 Hirudin, 193 Hispanics, 51

HMG CoA reductase inhibitors, 98-99

hypercholesterolemia, 134 Homeostasis model assessment

Hormonal abnormalities, treatment, future, 274 Hormone replacement therapy, 101-102 HOT, 72 HTGL, 89

Hydrochlorothiazide, hypertension, 134 Hypercholesterolemia, HMG CoA reduc-

tase inhibitors, 134 Hyperglycemia, 50 CAD, 187, 189 myocardial damage, 215 Hyperinsulinemia, 50 CAD, 187

insulin resistance, 68-69 thiazolidinediones, 182-183 Hyperinsulinemic glucose clamp technique, 142 Hyperlipidemia, 14, 50 Hyper(pro)insulinemia, 108 Hypertension, 50 CHF, 218, 226 clinical trials, 70-75 diabetes, type 1 vs. type 2, 66 genetics, 67

hydrochlorothiazide, 134 insulin resistance syndrome, 51-52 management, 75-77 nonpharmacological therapy, 75-76 obesity, schematic, 53 orthostatic, 76 pathogenesis, 67-69

[Hypertension] PCOS, 152-153, 157 prevalence, 66-67 sodium retention, 67-68 therapy, 191 pharmacological, 76-77 Hypertension Optimal Treatment

(HOT), 72 Hypertriglyceridemia, 120, 123

VLDL, 90-91 Hypoglycemia, 269 postexercise late onset, 269

ICAM, 141 IDL, 87

123I-metaiodobenzylguanidine (MIBC), 172 Impaired fasting glucose (IFG), 9-10, 20-21

Impaired glucose tolerance (IGT), 9-10,

138-139 Inhibin, PCOS, 153-154 Insulin, action, cellular events, 38-41 therapy, 96-97 Insulin receptor, 5, 39 Insulin receptor substrate 1 (IRS-1), 5 Insulin receptor substrate 2 (IRS-2), 5 Insulin receptor substrates (IRS), 24,

39-40, 137 Insulin resistance, 3-4 assessment, 35-56 blood pressure, 124-125 cause, 138 defined, 117-120 dyslipidemia, 123-124 Europe, 20 fibrinogen, 126

glucose metabolism, 121-122, 138139

historical development, 35-36 human disease characterized, 44 hyperinsulinemia, 68-69 importance, 120-126

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