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[Insulin resistance] measurement, 142-143 nature, 4-5 PAI-1, 125 PCOS, 126

procoagulant activity, 125-126 recognition, 35-56 reproductive system, 126 terminology, 35-36 type 2 diabetes, 37-43, 121 uric acid metabolism, 122-123 young adults, 22 Insulin Resistance and Atherosclerosis

Study (IRAS), 51 Insulin resistance syndrome, 19, 36, 47-54, 139-141 abnormal glucose metabolism, diagnosis, 141-142 atherosclerosis, 50-51 body composition, 47-48 clinical abnormalities, 37 dyslipidemia, 48-49 endothelial dysfunction, 49-50 hypertension, 51-52 laboratory abnormalities, 37 management, 54-56 obesity, 47-48

prothrombotic activity, 52-54 Tokyo, 20 treatment, 143-144 type 2 diabetes, macrovascular disease, 22-23 Insulin signaling cascade, 39, 43-45

schematic, 40 Insulin-stimulated glucose transport, 41-42 Insulin-stimulated glucose uptake, 45 Intercellular adhesion molecule (ICAM), 141

Interleukin-6 (IL-6), 141 Intermediate density lipoproteins (IDL), 87 Intestinal proteins, 88-89 Intra-abdominal tissue, CT, 48 MRI, 48 sonography, 48 Intravascular ultrasound (IVUS), CAD, 165

IRAS, 51

IVUS, CAD, 165

JNC-VI, 75-76, 191 Joint National Committee on Prevention, Detection and Treatment of High Blood Pressure, Sixth Report, 75-76, 191

Kidney-pancreas transplantation, 14

LACI, 107 LADA, 15

Latent autoimmune diabetes in adults

LDL (see Low-density lipoproteins) LDL receptor-related protein (LRP), 88 Lecithin cholesterol acetyltransferase

(LCAT), 92 Left ventricular function abnormalities, asymptomatic diabetics, 167 Left ventricular hypertrophy, 66 LIPID, 181

Lipid profiles, type 1 diabetes, insulin therapy, 17 Lipids, dietary, 88-89 endogenous, 90-92 fasting, metabolic abnormalities, 94 plasma, hypoglycemic agents, 97 postprandial, metabolic abnormalities, 89 Lipoprotein-associated coagulation inhibitor (LACI), 107 Lipoprotein lipase (LPL), 2, 88 Lipoproteins, 86

hypoglycemic agents, 97 metabolism, 88-95 physicochemical characteristics, 86 Lispro, 6 LMWH, 193

Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID), 181

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