There are several clinical, angiographic, and biological features particular to DM that increase the propensity for developing CAD in diabetic patients. In the aggregate, these risk factors increase the likelihood for sustaining a clinical event and have important prognostic implications. Endothelial dysfunction, platelet and coagulation abnormalities, and metabolic disorders associated with DM play a major role in accelerating the process of atherosclerosis and generating coronary thrombosis. The interplay of these factors and processes affects healing after arterial wall injury. The diffuse and distal nature of coronary atherosclerosis may contribute to incomplete revascularization and may increase the risk of surgical or percutaneous revascularization in diabetic patients.
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