T cell memory and the recall response

The development of FACS staining approaches utilizing tetrameric complexes 2 of MHC class I glycoprotein + peptide (tetramers) has greatly facilitated the analysis of both the effector and memory phases of virus-specific CD8+ T cell responses 20, 40 . This technology has moved more slowly for the CD4+ T cell subset 5, 6, 58 , partly because the comparable MHC class II + peptide reagents are more difficult to produce 129 , and partly because CD4+ T cell responses can tend to be both more diverse...

The virulence of the 1918 pandemic influenza virus unraveling the enigma

Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland Summary. The 1918 influenza pandemic caused acute illness in 25-30 of the world's population and resulted in the death of up to 40 million people. Using lung tissue of 1918 influenza victims, the complete genomic sequence of the 1918 influenza virus is being deduced. Neither the 1918 hemagglutinin nor neuraminidase genes possess mutations known to increase tissue tropicity that account for virulence of...

Emerging infectious diseases the publics view of the problem and what should be expected from the public health

The Burden Infectious Diseases 2016

National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, U.S.A. The public's view of major threats to health, as with other contemporary issues, is largely influenced by the media. As new health-related information is released from the clinical and research communities, it is translated for and disseminated to the public through a variety of mechanisms. In the past, healthcare providers served as the primary source of health-related information for...

Comments on the life and contributions of Robert E Shope

Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, U.S.A. I first met Bob Shope in 1965 in Brazil. At the time he was Director of the Rockefeller Foundation's Virus Laboratory at the Evandro Chagas Institute in Belem, and I was a young Peace Corps physician stationed in Recife. We remained friends for almost 40 years, and we worked together at the University of Texas Medical Branch UTMB and at Yale for 25 years....