External factors can also alter the immunological response in the skin. Ultraviolet light inactivates or destroys LCs in the skin (Alcalay et al., 1989). In the absence ofLCs, keratinocytes produce IL- 10 that prevents IFN-y production. Consequently, the immune response shifts to activation of Th2 cells. This T-cell subset plays a role in the induction of IgE-mediated allergic skin reactions (e.g., atopic dermatitis) and the induction of antibody-mediated autoimmune psoriasis (Nickoloff and Turka, 1994).
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