Immunoglobulin E

The IgE class has a chemical structure similar to IgG in that it consists ofthe basic H-Lstructure. Its molecular mass is higher than IgG because the heavy chains (e) have an extra constant domain (CH4). IgE is also unique in having a high carbohydrate content—12% versus 2-3% for the IgG subtypes.

IgE is associated with immediate allergic reactions such as asthma, rhinitis, and urticaria. Using Fee receptors, IgE attaches to fixed mast cells, and basophils in the blood.

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