Defect in ZAP70 Signaling

The ZAP-70 protein kinase has been reported to cause a unique immunodeficiency. This kinase is expressed on T cells and is associated with the CD3 Z chain of the TCR complex. TCR and ligand binding trigger the Src kinases that phosphorylate ITAMs on the Z chain. Tyrosine phosphorylation of proteins cannot occur in the presence of a defective ZAP-70. This results in a lack of mature CD8 cells in the peripheral blood and defective activation of CD4 cells (Fischer and Arnaiz-Villena, 1995).

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment