Approach To The Literature On Immunotherapy For Fungal Infections

The literature on immunotherapies for fungal infections consists of animal studies and human clinical data. In general, animal studies are usually well controlled and rigorously performed. In contrast, most of the information available about immunotherapy in humans comes from case reports and small studies. Hence, the reader must exercise caution when interpreting the human data and making inferences that are applicable to specific clinical situations. It is important to consider that the literature may be biased toward favorable outcomes since these are more likely to be reported than negative experiences. Firm conclusions about the value of specific types of immunotherapy for specific fungal infections must await the completion of well-controlled studies. Nevertheless, case reports and small studies provide important clinical information that can be used to design larger trials or guide heroic therapies in desperately ill patients with fungal infections refractory to standard therapy.

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