(a) Witebsky's postulates (which were modelled on those of Koch) require the presence of autoantibody or a cell-mediated immune response to a self-antigen.
(b) Clinically, autoimmune diseases have been divided into systemic or non-organ-specific and organ-specific.
(c) Systemic lupus erythematosus is a classical example of an organ-specific autoimmune disease.
(d) Non-organ-specific diseases may develop as a result of an abnormal immune response to a single antigen which is expressed in many tissues.
Was this article helpful?