Autoimmune diseases result from an abnormal immune response to self-antigens. In all these diseases, there is a breakdown of normal regulatory mechanisms and a lack of tolerance to the self-antigens concerned. The complex immunological responses that occur in these diseases are responsible for the resulting pathology and an understanding of these responses is vital for effective disease management.
Table 5.7 Target antigens involved in autoimmune diseases
Target antigens/potential target antigens
Acetyl choline receptor
Mitochondrial enzymes of the 2-oxo-acid dehydrogenase family
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