Are the Cognitive Changes During Acute Hypoglycaemia Important and Valid

Do the impairments of mental test performance actually have implications for real-life functions? In addition, are the mental changes during hypoglycaemia a result of impairments in basic brain functions?

One common, important and potentially dangerous area of real-life functioning is driving (see Chapter 14), which involves many cognitive abilities including psychomotor control and divided attention. Cox and colleagues (1993b; 2000) employed a sophisticated driving simulator and had people 'drive' on this during controlled hypoglycaemia using a glucose clamp technique. With very mild hypoglycaemia (blood glucose below 3.8mmol/l) the diabetic drivers committed significant driving errors, and during hypoglycaemia the patients often drove very slowly, possibly using a compensatory mechanism to avoid errors. Despite this, more global errors of driving were committed and about half of the participants, despite demonstrating a seriously impaired ability to drive, said they felt competent to drive irrespective of their low blood glucose! It cannot be stated with certainty that the findings obtained in a driving simulator will apply to real-life driving. However, studies that examine the practical cognitive effects of hypoglycaemia are invaluable and more are required.

Just as more studies that examine the practical cognitive aspects of hypoglycaemia would be useful, so would more studies of the brain's processing efficiency. Cognitive tests typically involve a melange of inseparable mental processes, and yet very specific aspects of the human brain's activities can be measured in the clinical laboratory (Massaro, 1993). Studies of the cognitive effects of hypoglycaemia have thus begun to address the impairments to various cognitive domains in more detail. Basic, specific aspects of visual and auditory processing have been examined during acute hypoglycaemia in non-diabetic humans. Standard tests of visual acuity - those that are measured by an optometrist - are not affected by hypoglycaemia, but other aspects of vision are affected (McCrimmon et al., 1996). These include:

• contrast sensitivity (the ability to discriminate faint patterns);

• inspection time (the ability to see what is in a pattern when it is shown for a very brief period of time);

• visual change detection (the ability to spot a small, quick change in a pattern);

• visual movement detection (the ability to spot brief movement in a pattern).

This means that the ability to see the environment changes in important ways during hypoglycaemia. Visual acuity is preserved, as tested by the ability to read black letters on a white background. However, most visual activity is not like that; many of the things we see happen quickly and in relatively poor light. When the level of contrast falls, or discriminations must be made under pressure of time, visual processing is impaired during hypoglycaemia. However, at about the same degree of hypoglycaemia, the ability to distinguish one colour from another does not appear to be impaired (Hardy et al., 1995). Speed of auditory processing also appears to be impaired by hypoglycaemia, and the ability to discriminate the loudness of two tones is disrupted (McCrimmon et al., 1997; Strachan et al., 2003). This suggests that the ability to understand language may be compromised during hypogly-caemia. However, despite there being disruption to central nervous system processing during hypoglycaemia, no disturbance has been detected in peripheral nerve conduction (Strachan et al., 2001).

If basic information processing provides a fundamental limitation to how well the brain is operating, then at a higher level of function, attention is important in carrying out a number of cognitive functions. A detailed study of a number of different aspects of attention during hypoglycaemia found that the abilities to attend selectively and to switch attention as necessary both deteriorated (McAulay et al., 2001a; 2005).

In turn, attention is necessary in order to learn and form new memories. There has now been detailed study of the different aspects of memory during acute, insulin-induced hypoglycaemia (Sommerfield et al., 2003a; 2003b; Deary et al., 2003). Most memory systems are disrupted during hypoglycaemia. However, some are especially badly affected: long-term memory, which is the ability to retain new information after many minutes and much distraction; working memory, which is the ability to retain and manipulate information at the same time; and prospective memory, which is the ability to remember to do things (as in a shopping list) (Warren et al., 2007). Indeed, the ability to perform one tricky working memory task was obliterated during hypoglycaemia (Deary et al., 2003). That is, no matter how good the person was at performing the task during euglycaemia, the same task could not be done during moderate hypoglycaemia.

Further information on hypoglycaemia and cognitive function is available in a review by Warren and Frier (2005).

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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