References

Eat Stop Eat

Best Weight Loss Programs That Work

Get Instant Access

1. L. de Lecea, T.S. Kilduff, C. Peyron, X. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L. Battenberg, V.T.

Gautvik, F.S. Bartlett, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik and J.G. Sutcliffe, The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity, Proc.NatlAcad.Sci.U.SA 95, 322-327 (1998).

2. T. Sakurai, Orexin: a link between energy homeostasis and adaptive behaviour, Curr.Opin.Clin.NutrMetab

3. T.L. Horvath and S. Diano, Opinion: The floating blueprint of hypothalamic feeding circuits,

4. J.G. Sutcliffe and L. De Lecea, The hypocretins: setting the arousal threshold, Nat.Rev.Neurosci. 3, 339-349

5. J.T. Willie, R.M. Chemelli, C.M. Sinton and M. Yanagisawa, To eat or to sleep? Orexin in the regulation of feeding and wakefulness, Annu. Rev. Neurosci. 24, 429-458 (2001).

6. C.B. Saper, T.C. Chou and T.E. Scammell, The sleep switch: hypothalamic control of sleep and wakefulness,

Trends Neurosci 24, 726-731 (2001).

7. E. Mignot, S. Taheri and S. Nishino, Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders, Nature Neuroscience 5 Suppl, 1071-1075 (2002).

8. S. Taheri, J.M. Zeitzer and E. Mignot, The role of hypocretins (orexins) in sleep regulation and narcolepsy,

9. A.V. Ferguson and W.K. Samson, The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function, Front Neuroendocrinol. 24, 141-150 (2003).

10. J.M. Siegel, Hypocretin (orexin): role in normal behavior and neuropathology, Annual Review of Psychology 55, 125-148 (2004).

11. Y. Kayaba, A. Nakamura, Y. Kasuya, T. Ohuchi, M. Yanagisawa, I. Komuro, Y. Fukuda and T. Kuwaki,

Attenuated defense response and low basal blood pressure in orexin knockout mice, Am.J Physiol Regul.Integr.Comp Physiol 285, R581-R593 (2003).

12. J.C. Geerling, T.C. Mettenleiter and A.D. Loewy, Orexin neurons project to diverse sympathetic outflow systems, Neuroscience 122, 541-550 (2003).

13. D. McGinty and R. Szymusiak, Hypothalamic regulation of sleep and arousal, Front Biosci. 8, s1074-s1083

14. K.S. Eriksson, O. Sergeeva, R.E. Brown and H.L. Haas, Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus, J. Neurosci. 21, 9273-9279 (2001).

15. K.S. Eriksson, D.R. Stevens and H.L. Haas, Serotonin excites tuberomammillary neurons by activation of

Na(+)/Ca(2+)-exchange, Neuropharmacology 40, 345-351 (2001).

16. K.S. Eriksson, O.A. Sergeeva, O. Selbach and H.L. Haas, Orexin (hypocretin)/dynorphin neurons control

GABAergic inputs to tuberomammillary neurons, Eur.J Neurosci. 19, 1278-1284 (2004).

17. O.A. Sergeeva, K.S. Eriksson, I.N. Sharonova, V.S. Vorobjev and H.L. Haas, GABA(A) receptor heterogeneity in histaminergic neurons, EurJ Neurosci. 16, 1472-1482 (2002).

18. O.A. Sergeeva, B.T. Amberger, K.S. Eriksson, A. Scherer and H.L. Haas, Co-ordinated expression of 5-

HT2C receptors with the NCX1 Na+/Ca2+ exchanger in histaminergic neurones, J Neurochem. 87, 657664 (2003).

19. O.A. Sergeeva, T.M. Korotkova, A. Scherer, R.E. Brown and H.L. Haas, Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones, J. Neurochem. 85, 1547-1552 (2003).

20. R.E. Brown, O.A. Sergeeva, K.S. Eriksson and H.L. Haas, Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline), J. Neurosci. 22, 8850-8859 (2002).

21. H. Haas and P. Panula, The role of histamine and the tuberomamillary nucleus in the nervous system,

22. T.M. Korotkova, O.A. Sergeeva, K.S. Eriksson, H.L. Haas and R.E. Brown, Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins, J. Neurosci. 23, 7-11 (2003).

23. T.M. Korotkova, H.L. Haas and R.E. Brown, Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro, Neuroscience Letters 320, 133-136 (2002).

24. T.M. Korotkova, K.S. Eriksson, H.L. Haas and R.E. Brown, Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro, Regulatory Peptides 104, 83-89 (2002).

25. J.P. Kukkonen, T. Holmqvist, S. Ammoun and K.E. Akerman, Functions of the orexinergic/hypocretinergic system, Am J Physiol Cell Physiol 283, C1567-C1591 (2002).

26. Y. Li, X.B. Gao, T. Sakurai and A.N. van den Pol, Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system, Neuron 36, 1169-1181 (2002).

27. A. Yamanaka, Y. Muraki, N. Tsujino, K. Goto and T. Sakurai, Regulation of orexin neurons by the monoaminergic and cholinergic systems, Biochem. Biophys. Res. Commun. 303, 120-129 (2003).

28. E. Eggermann, L. Bayer, M. Serafin, B. Saint-Mleux, L. Bernheim, D. Machard, B.E. Jones and M.

Muhlethaler, The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization, J. Neurosci. 23, 1557-1562 (2003).

29. O. Selbach, K.S. Eriksson and H.L. Haas, Drugs to interfere with orexins (hypocretins), Drug News

30. O. Selbach, N. Doreulee, C. Bohla, K.S. Eriksson, O.A. Sergeeva, W. Poelchen, R.E. Brown and H.L. Haas,

Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling, Neuroscience 127, 519-528 (2004).

31. A.A. Ponomarenko, J.S. Lin, O. Selbach and H.L. Haas, Temporal pattern of hippocampal high-frequency oscillations during sleep after stimulant-evoked waking, Neuroscience 121, 759-769 (2003).

32. C. Peyron, D.K. Tighe, A.N. van den Pol, L. De Lecea, H.C. Heller, J.G. Sutcliffe and T.S. Kilduff, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J. Neurosci. 18, 9996-10015 (1998).

33. B.A. Baldo, R.A. Daniel, C.W. Berridge and A.E. Kelley, Overlapping distributions of orexin/hypocretin-

and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress, J Comp Neurol. 464, 220-231 (2003).

34. Y. Date, Y. Ueta, H. Yamashita, H. Yamaguchi, S. Matsukura, K. Kangawa, T. Sakurai, M. Yanagisawa and M. Nakazato, Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems, Proc.NatlAcad.Sci.U.SA 96, 148-153 (1999).

35. C.B. Saper, THE CENTRAL AUTONOMIC NERVOUS SYSTEM: Conscious Visceral Perception and

Autonomic Pattern Generation, Annu. Rev. Neurosci. 25, 433-469 (2002).

36. A.D. Craig, How do you feel? Interoception: the sense of the physiological condition of the body,

Nat.Rev.Neurosci. 3, 655-666 (2002). 31. T. Bartsch, M.J. Levy, Y.E. Knight and P.J. Goadsby, Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area, Pain 109, 361-318 (2004).

38. J.N. Marcus, C.J. Aschkenasi, C.E. Lee, R.M. Chemelli, C.B. Saper, M. Yanagisawa and J.K. Elmquist,

Differential expression of orexin receptors 1 and 2 in the rat brain, J. Comp Neurol. 435, 6-25 (2001).

39. M. Wu, Z. Zhang, C. Leranth, C. Xu, A.N. van den Pol and M. Alreja, Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition, J Neurosci. 22, 1154-1165 (2002).

40. D. Burdakov, B. Liss and F.M. Ashcroft, Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger, J. Neurosci. 23, 4951-4951 (2003).

41. Q.V. Hoang, D. Bajic, M. Yanagisawa, S. Nakajima and Y. Nakajima, Effects of orexin (hypocretin) on

GIRK channels, J. Neurophysiol. 90, 693-102 (2003).

42. T.M. van den, M.F. Nolan, K. Lee, P.J. Richardson, R.M. Buijs, C.H. Davies and D. Spanswick, Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones, J.Physiol 549, 809-821 (2003).

43. P. Rouet-Benzineb, C. Rouyer-Fessard, A. Jarry, V. Avondo, C. Pouzet, M. Yanagisawa, C. Laboisse, M.

Laburthe and T. Voisin, Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis, J Biol.Chem. (2004).

44. D.E. Clapham, TRP channels as cellular sensors, Nature 426, 511-524 (2003).

45. M.P. Mattson, S.L. Chan and W. Duan, Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior, Physiol Rev. 82, 631-612 (2002).

46. F. Torrealba, M. Yanagisawa and C.B. Saper, Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats, Neuroscience 119, 1033-1044 (2003). 41. C. Acuna-Goycolea, Y. Li and A.N. van den Pol, Group III metabotropic glutamate receptors maintain tonic inhibition of excitatory synaptic input to hypocretin/orexin neurons, J Neurosci. 24, 3013-3022 (2004).

48. S. Satoh, H. Matsumura, A. Fujioka, T. Nakajima, T. Kanbayashi, S. Nishino, Y. Shigeyoshi and H.

Yoneda, FOS expression in orexin neurons following muscimol perfusion of preoptic area, Neuroreport 15, 1121-1131 (2004).

49. Y. Muraki, A. Yamanaka, N. Tsujino, T.S. Kilduff, K. Goto and T. Sakurai, Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor, J Neurosci. 24, 1159-1166 (2004).

50. T. Gallopin, P. Fort, E. Eggermann, B. Cauli, P.H. Luppi, J. Rossier, E. Audinat, M. Muhlethaler and M.

Serafin, Identification of sleep-promoting neurons in vitro, Nature 404, 992-995 (2000).

51. T.C. Chou, A.A. Bjorkum, S.E. Gaus, J. Lu, T.E. Scammell and C.B. Saper, Afferents to the ventrolateral preoptic nucleus, Journal of Neuroscience 22, 911-990 (2002).

52. O. Hayaishi and Z.L. Huang, Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission, Drug News Perspect. 17, 105-109 (2004).

53. T. Mochizuki, A. Crocker, S. McCormack, M. Yanagisawa, T. Sakurai and T.E. Scammell, Behavioral state instability in orexin knock-out mice, J Neurosci. 24, 6291-6300 (2004).

54. R.J. Liu, A.N. van den Pol and G.K. Aghajanian, Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions, J. Neurosci. 22, 9453-9464 (2002).

55. A.N. van den Pol, X.B. Gao, K. Obrietan, T.S. Kilduff and A.B. Belousov, Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin, J Neurosci. 18, 1962-1911 (1998).

56. K. Hirota, T. Kushikata, M. Kudo, T. Kudo, D.G. Lambert and A. Matsuki, Orexin A and B evoke noradrenaline release from rat cerebrocortical slices, Br. J. Pharmacol. 134, 1461-1466 (2001). 51. J. John, M.F. Wu, T. Kodama and J.M. Siegel, Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats, J.Physiol 548, 551-562 (2003).

58. J. Fadel, M. Bubser and A.Y. Deutch, Differential activation of orexin neurons by antipsychotic drugs associated with weight gain, J. Neurosci. 22, 6742-6746 (2002).

59. D. Kapfhamer, O. Valladares, Y. Sun, P.M. Nolan, J.J. Rux, S.E. Arnold, S.C. Veasey and M. Bucan,

Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse, Nature Genetics 32, 290-295 (2002).

60. G.G. Turrigiano and S.B. Nelson, Homeostatic plasticity in the developing nervous system, Nat. Rev.

61. A. Petersen, J. Gil, M.L.C. Maat-Schieman, M. Bjorkqvist, P. Mohapel, R. Araujo, N. Smith, N. Popovic,

N. Wierup, P. Norlen, J. Li, R.A.C. Ross, F. Sundler, H. Mulder and P. Brundin, Orexin loss - More evidence for hypothalamic dysfunction in Huntington's disease, Soc Neurosci Abstr. 564.1, (2004).

62. J.A. Hobson and E.F. Pace-Schott, The cognitive neuroscience of sleep: neuronal systems, consciousness and learning, Nat.Rev.Neurosci. 3, 679-693 (2002).

63. E.F. Pace-Schott and J.A. Hobson, The neurobiology of sleep: genetics, cellular physiology and subcortical networks, Nat.Rev.Neurosci. 3, 591-605 (2002).

64. A. Knoche, H. Yokoyama, A. Ponomarenko, C. Frisch, J. Huston and H.L. Haas, High-frequency oscillation in the hippocampus of the behaving rat and its modulation by the histaminergic system, Hippocampus 13, 273-280 (2003).

65. A.A. Ponomarenko, A. Knoche, T.M. Korotkova and H.L. Haas, Aminergic control of high-frequency

(approximately 200 Hz) network oscillations in the hippocampus of the behaving rat, Neuroscience Letters 348, 101-104 (2003).

66. A.N. van den Pol, P.K. Ghosh, R.J. Liu, Y. Li, G.K. Aghajanian and X.B. Gao, Hypocretin (orexin)

enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus, J Physiol 541, 169-185 (2002).

67. A. Peters, U. Schweiger, L. Pellerin, C. Hubold, K.M. Oltmanns, M. Conrad, B. Schultes, J. Born and H.L.

Fehm, The selfish brain: competition for energy resources, Neuroscience and Biobehavioral Reviews 28, 143-180 (2004).

68. G. Buzsaki and A. Draguhn, Neuronal oscillations in cortical networks, Science 304, 1926-1929 (2004).

69. R. Parmentier, H. Ohtsu, Z. Djebbara-Hannas, J.L. Valatx, T. Watanabe and J.S. Lin, Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control, J Neurosci 22, 7695-7711 (2002).

70. J.S. Lin, Y. Hou, K. Sakai and M. Jouvet, Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat, J Neurosci. 16, 1523-1537

71. J. John, M.F. Wu, L.N. Boehmer and J.M. Siegel, Cataplexy-active neurons in the hypothalamus:

implications for the role of histamine in sleep and waking behavior, Neuron 42, 619-634 (2004).

72. S.P. Kalra, M.G. Dube, S. Pu, B. Xu, T.L. Horvath and P.S. Kalra, Interacting appetite-regulating pathways in the hypothalamic regulation of body weight, Endocrine Reviews 20, 68-100 (1999).

73. M. Kummer, S.J. Neidert, O. Johren and P. Dominiak, Orexin (hypocretin) gene expression in rat ependymal cells, Neuroreport 12, 2117-2120 (2001).

74. T. Porkka-Heiskanen, R.E. Strecker, M. Thakkar, A.A. Bjorkum, R.W. Greene and R.W. McCarley,

Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness, Science 276, 1265-1268

75. J.A. Murphy, S. Deurveilher and K. Semba, Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat, Neuroscience 121, 269-275 (2003).

76. M.M. Thakkar, S. Winston and R.W. McCarley, Orexin neurons of the hypothalamus express adenosine A1

receptors, Brain Research 944, 190-194 (2002).

77. H.L. Haas and O. Selbach, Functions of neuronal adenosine receptors, Naunyn Schmiedebergs Arch.

Pharmacol. 362, 375-381 (2000).

78. L.E. Nelson, T.Z. Guo, J. Lu, C.B. Saper, N.P. Franks and M. Maze, The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway, Nature Neuroscience 5, 979-984 (2002).

79. I. Inoue, K. Yanai, D. Kitamura, I. Taniuchi, T. Kobayashi, K. Niimura, T. Watanabe and T. Watanabe,

Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors, Proc. Natl. Acad Sci U. SA 93, 13316-13320 (1996).

80. H. Yoshimatsu, E. Itateyama, S. Kondou, D. Tajima, K. Himeno, S. Hidaka, M. Kurokawa and T. Sakata,

Hypothalamic neuronal histamine as a target of leptin in feeding behavior, Diabetes 48, 2286-2291 (1999).

81. A. Mollet, T.A. Lutz, S. Meier, T. Riediger, P.A. Rushing and E. Scharrer, Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin, Am. J Physiol Regul. Integr. Comp Physiol 281, R1442-R1448 (2001).

82. L. Lin, J. Wisor, T. Shiba, S. Taheri, K. Yanai, S. Wurts, X. Lin, M. Vitaterna, J. Takahashi, T.W.

Lovenberg, M. Koehl, G. Uhl, S. Nishino and E. Mignot, Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background, Peptides 23, 2203-22ll (2002).

83. L. Lin, J. Faraco, R. Li, H. Kadotani, W. Rogers, X. Lin, X. Qiu, P.J. de Jong, S. Nishino and E. Mignot,

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene, Cell 98, 365-376 (l999).

84. J.O. Rinne, O.V. Anichtchik, K.S. Eriksson, J. Kaslin, L. Tuomisto, H. Kalimo, M. Roytta and P. Panula,

Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy, J Neurochem. 81, 954-960 (2002).

85. M. Wu, L. Zaborszky, T. Hajszan, A.N. van den Pol and M. Alreja, Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons, JNeurosci. 24, 3527-3536 (2004).

86. M.S. Duxon, J. Stretton, K. Starr, D.N. Jones, V. Holland, G. Riley, J. Jerman, S. Brough, D. Smart, A.

Johns, W. Chan, R.A. Porter and N. Upton, Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-l (OXl) receptors, with downstream 5-HT2C receptor involvement, Psychopharmacology (Berl) 153, 203-209 (200l).

87. D.R. Stevens, A. Kuramasu, K.S. Eriksson, O. Selbach and H.L. Haas, alpha(2)-Adrenergic receptor-

mediated presynaptic inhibition of GABAergic IPSPs in rat histaminergic neurons, Neuropharmacology 46, l0l8-l022 (2004).

88. T.C. Chou, C.E. Lee, J. Lu, J.K. Elmquist, J. Hara, J.T. Willie, C.T. Beuckmann, R.M. Chemelli, T. Sakurai,

M. Yanagisawa, C.B. Saper and T.E. Scammell, Orexin (hypocretin) neurons contain dynorphin, J. Neurosci. 21, RCl68 (200l).

89. X.H. Liu, R. Morris, D. Spiller, M. White and G. Williams, Orexin a preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro, Diabetes 50, 243l-2437 (200l).

90. A. Yamanaka, C.T. Beuckmann, J.T. Willie, J. Hara, N. Tsujino, M. Mieda, M. Tominaga, K. Yagami, F.

Sugiyama, K. Goto, M. Yanagisawa and T. Sakurai, Hypothalamic orexin neurons regulate arousal according to energy balance in mice, Neuron 38, 70l-7l3 (2003).

91. I.V. Estabrooke, M.T. McCarthy, E. Ko, T.C. Chou, R.M. Chemelli, M. Yanagisawa, C.B. Saper and T.E.

Scammell, Fos expression in orexin neurons varies with behavioral state, J. Neurosci. 21, l656-l662 (200l).

92. J.M. Zeitzer, C.L. Buckmaster, K.J. Parker, C.M. Hauck, D.M. Lyons and E. Mignot, Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness, J. Neurosci. 23, 3555-3560 (2003).

93. D. Teves, T.O. Videen, P.E. Cryer and W.J. Powers, Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia, Proc.NatlAcad.Sci.U.SA 101, 62l7-622l (2004).

94. J. Hara, C.T. Beuckmann, T. Nambu, J.T. Willie, R.M. Chemelli, C.M. Sinton, F. Sugiyama, K. Yagami, K.

Goto, M. Yanagisawa and T. Sakurai, Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity, Neuron 30, 345-354 (200l).

95. S. Overeem, J.A. van Vliet, G.J. Lammers, F.G. Zitman, D.F. Swaab and M.D. Ferrari, The hypothalamus in episodic brain disorders, Lancet Neurol. 1, 437-444 (2002).

96. S. Nishino and E. Mignot, Pharmacological aspects of human and canine narcolepsy, Progress in Neurobiology 52, 27-78 (l997).

97. K. Nonogaki, A.M. Strack, M.F. Dallman and L.H. Tecott, Leptin-independent hyperphagia and type 2

diabetes in mice with a mutated serotonin 5-HT2C receptor gene, Nat. Med. 4, ll52-ll56 (l998).

98. C. Schmauss, Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing, Neuroscientist. 9, 237

99. I. Matsuzaki, T. Sakurai, K. Kunii, T. Nakamura, M. Yanagisawa and K. Goto, Involvement of the serotonergic system in orexin-induced behavioral alterations in rats, Regulatory Peptides 104, ll9-l23 (2002).

100. B. Borowsky, M.M. Durkin, K. Ogozalek, M.R. Marzabadi, J. DeLeon, B. Lagu, R. Heurich, H. Lichtblau, Z. Shaposhnik, I. Daniewska, T.P. Blackburn, T.A. Branchek, C. Gerald, P.J. Vaysse and C. Forray, Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist, Nat. Med. 8, 825-830 (2002).

101. J.M. Swanson, Role of executive function in ADHD, J. Clin. Psychiatry 64 Suppl 14, 35-39 (2003).

102. R.M. Salomon, B. Ripley, J.S. Kennedy, B. Johnson, D. Schmidt, J.M. Zeitzer, S. Nishino and E. Mignot, Diurnal variation of cerebrospinal fluid hypocretin-l (Orexin-A) levels in control and depressed subjects, Biol. Psychiatry 54, 96-l04 (2003).

103. M. Monda, A.N. Viggiano, A.L. Viggiano, F. Fuccio and L. De, V, Cortical spreading depression blocks the hyperthermic reaction induced by orexin A, Neuroscience 123, 567-574 (2004).

104. A. Gutierrez, G. Saracibar, L. Casis, E. Echevarria, V.M. Rodriguez, M.T. Macarulla, L.C. Abecia and M.P. Portillo, Effects of fluoxetine administration on neuropeptide y and orexins in obese zucker rat hypothalamus, Obesity Research 10, 532-540 (2002).

105. L.E. Krahn, W.R. Moore and S.I. Altchuler, Narcolepsy and obesity: remission of severe cataplexy with sibutramine, Sleep Med. 2, 63-65 (2001).

106. A.E. Kelley and K.C. Berridge, The neuroscience of natural rewards: relevance to addictive drugs, J Neurosci. 22, 3306-3311 (2002).

107. R.A. Wise, Dopamine, learning and motivation, Nat.Rev.Neurosci. 5, 483-494 (2004).

108. R.J. DiLeone, D. Georgescu and E.J. Nestler, Lateral hypothalamic neuropeptides in reward and drug addiction, Life Sciences 73, 759-768 (2003).

109. B. Boutrel, P.J. Kenny, S.E. Specio, A. Markou, G.F. Koob and L. De Lecea, Hypocretin regulates brain reward function and reinstatement of cocaine seeking behavior in rats, Soc Neurosci Abstr. 573.2, (2004).

110. X. Drouot, S. Moutereau, J.P. Nguyen, J.P. Lefaucheur, A. Creange, P. Remy, F. Goldenberg and M.P. d'Ortho, Low levels of ventricular CSF orexin/hypocretin in advanced PD, Neurology 61, 540-543 (2003).

111. B. Boutre, P.J. Kenny, S.E. Specio, A. Markou, G.F. Koob and L. De Lecea, Hypocretin regulates brain reward function and reinstatement of cocaine seeking behavior in rats, Soc Neurosci Abstr. 573.2, (2004).

112. J.P. Wisor, S. Nishino, I. Sora, G.H. Uhl, E. Mignot and D.M. Edgar, Dopaminergic role in stimulant-induced wakefulness, J. Neurosci. 21, 1787-1794 (2001).

113. R.M. Chemelli, J.T. Willie, C.M. Sinton, J.K. Elmquist, T. Scammell, C. Lee, J.A. Richardson, S.C. Williams, Y. Xiong, Y. Kisanuki, T.E. Fitch, M. Nakazato, R.E. Hammer, C.B. Saper and M. Yanagisawa, Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation, Cell 98, 437451 (1999).

114. T.E. Scammell, I.V. Estabrooke, M.T. McCarthy, R.M. Chemelli, M. Yanagisawa, M.S. Miller and C.B. Saper, Hypothalamic arousal regions are activated during modafinil-induced wakefulness, J. Neurosci. 20, 8620-8628 (2000).

115. M.M. Thakkar, R.E. Strecker and R.W. McCarley, Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons, Brain Research 945, 276-280 (2002).

116. J. Fadel and A.Y. Deutch, Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area, Neuroscience 111, 379-387 (2002).

117. K. Uramura, H. Funahashi, S. Muroya, S. Shioda, M. Takigawa and T. Yada, Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area, Neuroreport 12, 1885-1889 (2001).

118. S. Diano, B. Horvath, H.F. Urbanski, P. Sotonyi and T.L. Horvath, Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets, Endocrinology 144, 3774-3778 (2003).

119. S. Nishino, N. Fujiki, B. Ripley, E. Sakurai, M. Kato, T. Watanabe, E. Mignot and K. Yanai, Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs, Neuroscience Letters 313, 125-128 (2001).

120. G. Telegdy and A. Adamik, The action of orexin A on passive avoidance learning. Involvement of transmitters, Regulatory Peptides 104, 105-110 (2002).

121. S.H. Russell, M.S. Kim, C.J. Small, C.R. Abbott, D.G. Morgan, S. Taheri, K.G. Murphy, J.F. Todd, M.A. Ghatei and S.R. Bloom, Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin, J. Neuroendocrinol. 12, 1213-1218 (2000).

122. Y.C. Hsueh, S.M. Cheng and J.T. Pan, Fasting stimulates tuberoinfundibular dopaminergic neuronal activity and inhibits prolactin secretion in oestrogen-primed ovariectomized rats: involvement of orexin A and neuropeptide Y, J. Neuroendocrinol. 14, 745-752 (2002).

123. J.J. Hagan, R.A. Leslie, S. Patel, M.L. Evans, T.A. Wattam, S. Holmes, C.D. Benham, S.G. Taylor, C. Routledge, P. Hemmati, R.P. Munton, T.E. Ashmeade, A.S. Shah, J.P. Hatcher, P.D. Hatcher, D.N. Jones, M.I. Smith, D.C. Piper, A.J. Hunter, R.A. Porter and N. Upton, Orexin A activates locus coeruleus cell firing and increases arousal in the rat, Proc.NatlAcad.Sci.U.SA 96, 10911-10916 (1999).

124. P. Bourgin, S. Huitron-Resendiz, A.D. Spier, V. Fabre, B. Morte, J.R. Criado, J.G. Sutcliffe, S.J. Henriksen and L. De Lecea, Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons, J. Neurosci. 20, 7760-7765 (2000).

125. T.L. Horvath, C. Peyron, S. Diano, A. Ivanov, G. Aston-Jones, T.S. Kilduff and A.N. van den Pol, Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system, J Comp Neurol. 415, 145-159 (1999).

126. J. Grivel, I. Tobler, M. Muhlethaler and M. Serafin, Following sleep deprivation the excitation of rat hypocretin/orexin neurons by noradrenaline reverses to inhibition, Soc Neurosci Abstr. 318.8., (2004).

127. G. Aston-Jones, S. Chen, Y. Zhu and M.L. Oshinsky, A neural circuit for circadian regulation of arousal, Nat. Neurosci. 4, 732-738 (2001).

128. S.G. Walling, D.J. Nutt, M.D. Lalies and C.W. Harley, Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long-term potentiation in the dentate gyrus, J Neurosci. 24, 7421-7426 (2004).

129. C.F. Murchison, X.Y. Zhang, W.P. Zhang, M. Ouyang, A. Lee and S.A. Thomas, A distinct role for norepinephrine in memory retrieval, Cell 117, 131-143 (2004).

130. S. Burlet, C.J. Tyler and C.S. Leonard, Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy, J. Neurosci. 22, 2862-2872 (2002).

131. E. Eggermann, M. Serafin, L. Bayer, D. Machard, B. Saint-Mleux, B.E. Jones and M. Muhlethaler, Orexins/hypocretins excite basal forebrain cholinergic neurones, Neuroscience 108, 177-181 (2001).

132. D.E. Berman and Y. Dudai, Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex, Science 291, 2417-2419 (2001).

133. L.A. Graves, K. Hellman, S. Veasey, J.A. Blendy, A.I. Pack and T. Abel, Genetic evidence for a role of CREB in sustained cortical arousal, J Neurophysiol. 90, 1152-1159 (2003).

134. A.B. Belousov, B.F. O'Hara and J.V. Denisova, Acetylcholine becomes the major excitatory neurotransmitter in the hypothalamus in vitro in the absence of glutamate excitation, J Neurosci. 21, 20152027 (2001).

135. L. Bayer, E. Eggermann, B. Saint-Mleux, D. Machard, B.E. Jones, M. Muhlethaler and M. Serafin, Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons, J. Neurosci. 22, 7835-7839 (2002).

136. L. Bayer, M. Serafin, E. Eggermann, B. Saint-Mleux, D. Machard, B.E. Jones and M. Muhlethaler, Exclusive postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons, J Neurosci. 24, 67606764 (2004).

137. C. Cirelli, C.M. Gutierrez and G. Tononi, Extensive and divergent effects of sleep and wakefulness on brain gene expression, Neuron 41, 35-43 (2004).

138. E.K. Lambe and G.K. Aghajanian, Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice, Neuron 40, 139-150 (2003).

139. R. Lathe, Hormones and the hippocampus, J Endocrinol. 169, 205-231 (2001).

140. M.J. Wayner, D.L. Armstrong, C.F. Phelix and Y. Oomura, Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo, Peptides 25, 991-996 (2004).

141. D. Gerashchenko, R. Salin-Pascual and P.J. Shiromani, Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal theta, Brain Research 913, 106-115 (2001).

142. O. Selbach, C. Bohla, N. Doreulee, K.S. Eriksson, O.A. Sergeeva and H.L. Haas, Rapid protein synthesis-dependent synaptic plasticity in the hippocampus by orexins/hypocretins., FENSAbstr. A084.22., (2004).

143. S. Aou, X.L. Li, A.J. Li, Y. Oomura, T. Shiraishi, K. Sasaki, T. Imamura and M.J. Wayner, Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats, Neuroscience 119, 1221-1228 (2003).

144. L.B. Jaeger, S.A. Farr, W.A. Banks and J.E. Morley, Effects of orexin-A on memory processing, Peptides 23, 1683-1688 (2002).

145. U. Steidl, S. Bork, S. Schaub, O. Selbach, J. Seres, M. Aivado, T. Schroeder, U.P. Rohr, R. Fenk, S. Kliszewski, C. Maercker, P. Neubert, S.R. Bornstein, H.L. Haas, G. Kobbe, D.G. Tenen, R. Haas and R. Kronenwett, Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators, Blood 104, 81-88 (2004).

Was this article helpful?

0 0
An Addict's Guide To Freedom

An Addict's Guide To Freedom

Get All The Support And Guidance You Need To Be A Success At Understanding And Getting Rid Of Addictions. This Book Is One Of The Most Valuable Resources In The World When It Comes To New Ways To Understand Addicts And Get Rid Of Addictions.

Get My Free Ebook


Post a comment