Intra-LHA connections were evident already from tracing studies; notably, a small degree of innervation contralateral to the tracer injection site could even be noted.7374 Accordingly, mappings of MCH- and Hcrt-ir fibres revealed dense local plexuses within the LHA.163275 Cell bodies containing MCH- and Hcrt-LI are frequently observed right next to each other, and at the light microscopic level the two cell types are seen contributing boutons apposed to the soma of the other.5676 Ultrastructural studies have confirmed that the two types of neurons supply reciprocal synaptic specializations onto each other.34 However, the Hcrt-ir terminals, which form asymmetrical (i.e. excitatory) contacts onto MCH-ir somata and dendrites, appear comparatively more extensive than MCH-ir terminals onto Hcrt neurons.34 (see also ref 77)
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