We thank Pablo Henny, Mandana Modirrousta, Maan Gee Lee and Lynda Mainville in Montreal and Mauro Serafin, Emmanuel Eggermann, Laurence Bayer and Daniel Machard in Geneva for their original contributions to the work reviewed in this chapter. We also thank James Galaty for assistance with the illustrations. Original research was supported by grants from the Canadian Institutes of Health Research (CIHR) and U.S. National Institutes of Health (NIH) to BEJ in Montreal and by the Fonds National Swiss to MM in Geneva.

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