Because calcium channel blockers have neutral effects on lipid and glucose metabolism, they are appropriate for patients with metabolic syndrome. Clinical outcome trials, such as the hypertension optimal treatment (HOT) trial (20) and the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) (21) showed that calcium channel blockers are safe and effective in controlling blood pressure and reducing CVD events in patients with diabetes. Side effects associated with vasodilatation, such as flushing, headache, and ankle edema, can be troublesome.
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