Vasa Recta

In order for the countercurrent multiplier system to be effective, most of the salt that is extruded from the ascending limbs must remain in the interstitial fluid of the medulla, while most of the water that leaves the descending limbs must be removed by the blood. This is accomplished by the vasa recta—long, thin-walled vessels that parallel the loops of Henle of the jux-tamedullary nephrons (see fig. 17.19). The descending vasa recta have characteristics of both capillaries and arterioles because their continuous endothelium is surrounded by smooth muscle remnants. These vessels have urea transporters (for fa-cilitative diffusion) and aquaporin proteins, which function as water channels through the membrane (chapter 6). The ascending vasa recta are capillaries with a fenestrated endothelium. As described in chapter 13, the wide gaps between endothelial cells in such capillaries permit rapid rates of diffusion.

The vasa recta maintain the hypertonicity of the renal medulla by means of a mechanism known as countercurrent exchange. Salt and other dissolved solutes (primarily urea, described in the next section) that are present at high concentrations in the interstitial fluid diffuse into the descending vasa recta. However, these same solutes then passively diffuse out of the ascending vasa recta and back into the interstitial fluid to complete the countercurrent exchange. They do this because, at each level of the medulla, the concentration of solutes is higher in the ascending vessels than in the interstitial fluid, and higher in the interstitial fluid than in the descending vessels. Solutes are thus recirculated and trapped within the medulla.

The walls of the vasa recta are freely permeable to water and to dissolved NaCl and urea. Plasma proteins, however, do not easily pass through the capillary walls of the vasa recta. The colloid osmotic pressure (oncotic pressure) within the vasa recta, therefore, is higher than in the surrounding interstitial fluid. This is similar to the situation in other capillary beds (chapter 14) and results in the osmotic movement of water into both the descending and ascending limbs of the vasa recta. The vasa recta thus trap salt and urea within the interstitial fluid but transport water out of the renal medulla (fig. 17.17).

Renal Countercurrent
Black arrows = diffusion of NaCl and urea Blue arrows = movement of water by osmosis

■ Figure 17.17 Countercurrent exchange in the vasa recta. The diffusion of salt and water first into and then out of these blood vessels helps to maintain the "saltiness" (hypertonicity) of the interstitial fluid in the renal medulla. (Numbers indicate osmolality.)

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  • maria rosa
    How vasa recta exchange water for salt?
    8 years ago
  • birikti
    What is present in the vasa recta to remove water for the interstitial fluid of the renal medulla?
    8 years ago
  • eleleta
    Is descending vasa recta permeable to salt?
    8 years ago
  • Filmon
    How vasa recta effects on blood pressure?
    7 years ago
  • adelaide ferrari
    What is the vasa recta in the nephron physiology?
    7 years ago
  • Veera
    How does vasa recta and urea contribute to countercurrent multiplication system?
    7 years ago
  • sirja
    What blood vessels run parallel to the nephron vasa recta?
    7 years ago
  • Annika
    Does urea effect vesa recta?
    7 years ago
  • Mirabella
    Is vasa recta permeable to proteins?
    5 years ago
  • petra
    How vasa recta maintain hypertonic interstitium?
    2 years ago
  • ermias
    Why water comes out into interstial fluid from descending limb of vasa recta?
    2 years ago
  • florian
    Why vasa recta is permeable to solute?
    2 years ago
  • Uwe
    Is vasa recta impermeable for urea?
    2 years ago
  • cedivar
    How do the endothelial cells of the vasa recta transport water into the blood?
    2 years ago
    How does vasa recta function in human kidneys?
    1 year ago
    Why descending limb of vasa rectae removes water?
    1 year ago
  • Vito Nucci
    What do the vasa recta capillaries do?
    7 months ago
  • Satu
    How does nacl leave the vasa recta?
    14 days ago
  • Furuta
    What does Laura learn in reviewing the role of the vasa recta in blood pressure regulation?
    2 days ago

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