Plasma albumin and most of the plasma globulins (with the exception of immunoglobulins, or antibodies) are produced by the liver. Albumin constitutes about 70% of the total plasma protein and contributes most to the colloid osmotic pressure of the blood (chapter 14). The globulins produced by the liver have a wide variety of functions, including transport of cholesterol and triglycerides, transport of steroid and thyroid hormones, inhibition of trypsin activity, and blood clotting. Clotting factors I (fibrinogen), II (prothrombin), III, V, VII, IX, and XI, as well as angiotensinogen, are all produced by the liver.
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