Metabolic Regulation

The cerebral arterioles are exquisitely sensitive to local changes in metabolic activity, so that those brain regions with the highest metabolic activity receive the most blood. Indeed, areas of the brain that control specific processes have been mapped by the changing patterns of blood flow that result when these areas are activated. Visual and auditory stimuli, for example, increase blood flow to the appropriate sensory areas of the cerebral cortex, whereas motor activities, such as movements of the eyes, arms, and organs of speech, result in different patterns of blood flow (fig. 14.21).

The exact mechanisms by which increases in neural activity in a particular area of the brain elicit local vasodilation are not completely understood. There is evidence, however, that local cerebral vasodilation may be caused by K+ which is released from active neurons during repolarization. It has been proposed that astrocytes may take up this extruded K+ near the active neurons and then release the K+ through their vascular processes (chapter 7; see fig. 7.10) that surround arterioles, thereby causing the arterioles to dilate.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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