End Product Inhibition

The activities of enzymes at the branch points of metabolic pathways are often regulated by a process called end-product inhibition, which is a form of negative feedback inhibition. In this process, one of the final products of a divergent pathway inhibits the activity of the branch-point enzyme that began the path toward the production of this inhibitor. This inhibition prevents that final product from accumulating excessively and results in a shift toward the final product of the alternate pathway (fig. 4.9).

The mechanism by which a final product inhibits an earlier enzymatic step in its pathway is known as allosteric inhibition. The allosteric inhibitor combines with a part of the enzyme at a location other than the active site. This causes the active site to change shape so that it can no longer combine properly with its substrate.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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  • selina fairbairn
    What is an end product in physiology?
    8 years ago

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