Since aldosterone promotes Na+ retention and K+ loss, one might predict (on the basis of negative feedback) that aldosterone secretion would be increased when there was a low Na+ or a high K+ concentration in the blood. This indeed is the case. A rise in blood K+ directly stimulates the secretion of aldosterone from the adrenal cortex. A decrease in plasma Na+ concentration, if it causes a fall in blood volume, also promotes aldosterone secretion. However, the stimulatory effect of a fall in blood volume on aldosterone secretion is indirect, as described in the next section.
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