Timothy's past drug abuse could have resulted in the development of an extensive smooth endoplasmic reticulum, which contains many of the enzymes required to metabolize drugs. Liver disease could have been caused by the drug abuse, but there is an alternative explanation. The low amount of the enzyme that breaks down glycogen signals the presence of glycogen storage disease, a genetic condition in which a key lysosomal enzyme is lacking. This enzymatic evidence is supported by the observations of large amounts of glycogen granules and the lack of partially digested glycogen granules within secondary lysosomes. (In reality, such a genetic condition would more likely be diagnosed in early childhood.)

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