Aerobic Requirements of the Heart

The coronary arteries supply an enormous number of capillaries, which are packed within the myocardium at a density ranging from 2,500 to 4,000 per cubic millimeter of tissue. Fast-twitch skeletal muscles, by contrast, have a capillary density of 300 to 400 per cubic millimeter of tissue. Each myocardial cell, as a consequence, is within 10 |im of a capillary (compared to an average distance in other organs of 70 |im). The exchange of gases by diffusion between myocardial cells and capillary blood thus occurs very quickly.

Contraction of the myocardium squeezes the coronary arteries. Unlike blood flow in all other organs, flow in the coronary vessels thus decreases in systole and increases during diastole. The myocardium, however, contains large amounts of myoglobin, a pigment related to hemoglobin (the molecules in red blood cells that carry oxygen). Myoglobin in the myocardium stores oxygen during diastole and releases its oxygen during systole. In this way, the myocardial cells can receive a continuous supply of oxygen even though coronary blood flow is temporarily reduced during systole.

In addition to containing large amounts of myoglobin, heart muscle contains numerous mitochondria and aerobic respiratory enzymes. This indicates that—even more than slow-twitch skeletal muscles—the heart is extremely specialized for aerobic respiration. The normal heart always respires aerobi-cally, even during heavy exercise when the metabolic demand for oxygen can rise to five times resting levels. This increased oxygen requirement is met by a corresponding increase in coronary blood flow, from about 80 ml at rest to about 400 ml per minute per 100 g tissue during heavy exercise.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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