Unm Hiaith Soenck Centek Unwhy

1 Altachmeril

2 Penetration

3 Uncoating

4 Transcription of early mRNA

5 Translation of early proteins

6 Replication of viral DNA

7 Transcription ol late mRNA

8 Translation ol late proteins

9 Assembly ol virions

1 Altachmeril

2 Penetration

3 Uncoating

4 Transcription of early mRNA

5 Translation of early proteins

6 Replication of viral DNA

7 Transcription ol late mRNA

8 Translation ol late proteins

9 Assembly ol virions

Fig. 3-2 General features of the viral replication cycle, using a m men ve loped DNA virus as a model No topographic location tor any step is implied One step grades mlo the nexl such that, as the tyde progresses, several processes are proceeding simultaneously other cellular enzymes, but most have their own genes for a range of other enzymes. In addition, some carry "transforming genes" which induce cellulai DNA synthesis, to increase the concentration of cellular enzymes and deoxy-nucleotides to the levels found only during the S phase of the mitotic cycle.

RNA viruses have the advantage that ribonucleoside triphosphates are available throughout the cell cycle. However, these viruses must encode their own RNA polymerase(s), since cells lack the capacity to copy RNA from an RNA template Most RNA viruses replicate in the cytoplasm (lable 3-1).

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