Routes of Entry 87
Mechanisms of Spread in the Body 92
Virus Shedding 100
To cause infection, viruses, like other infectious agents, must gain entry to the body, multiply, and spread, either locally or systemically, and in generalized infections localize in the appropriate target organ. To be maintained in nature, infectious virions must be shed into the environment, or taken up by an arthropod vector or a needle, or passed congenially,
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