Hepatocellular carcinoma

Fig. 22-4 Clinical outcomes of hepatitis B virus infection

Some chronic carriers of hepatitis B virus can have a number of such abortive seroconversions in a lifetime, resulting in the development of quite severe liver disease. Chronic infection with HBV can result in the development of chronic liver disease characterized by chronic persistent hepatitis, chronic active hepatitis, and cirrhosis. Some carriers have a very poor prognosis, developing rapidly progressive liver disease, whereas other carriers have a much more benign prognosis.

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